Carisoprodol 500mg prescription free
99% like it View all 1678 reviews $0.32 - $2.85 per pill

buy drug soma 500mg in australia


Another factor that soma 50 mg must be kept in mind is thatcharged solid carisoprodol 500mg prescription example surfaces, such as polyelectrolytes, will stronglyadsorb oppositely charged solutes. It is recommended that there be at least 10 days’ treatment forany infection caused bystreptococcus pyogenesto prevent the occurrence of acute rheumatic fever.h. An obvious example would be the combination of organicamines and acids, which are charged oppositely and would beexpected to interact strongly. However, for many ofthese products, new delivery systems are being evaluated as tramadol 200mg prescription drug test de-scribed below.characterization of the products produced by pharmaceu-tical biotechnology is a rapidly changing technical challenge,but tremendous advances have been made in the past decade.the fda considers most of these products (other than some ofthe vaccines) to be well characterized and has changed the ap-proach to license approval with this improved understanding ofproduct specifications in mind. Peculiar penile events during wakefulness and slow wave sleep in the armadillo. 10, or 20 mg) that were instructed to attempt intercourse at 2 different times (24 and 36 hours post-dosing). As been shown to significantly improve theability of obtaining a hard erect penis suitable for sexual activity.contains the active substance tadalafil which belongs to a group of medicines calledphosphodiesterase type 5 inhibitors. In malignant malaria, quinineis best given intravenously in fifteen-grain doses repeated if necessaryafter six hours; for this purpose the hydrochloride dissolved in warmsaline is the best preparation, the more soluble acid salts tending toreact with carisoprodol 500mg prescription free the blood proteins. Hence, biologi-cal test procedures are used to determine the suitability of aplastic for packaging products intended for parenteral use andfor polymers intended for use in implants and medical devices.systemic injection and intracutaneous and implantation testsare employed. Physostigmine is excreted rather rapidly and mainly in theurine, although it has been found in traces in the bile and saliva.the symptoms of poisoning consist of giddiness, anxiety,dyspnoea, excitement, palpitation carisoprodol 500mg prescription free of the heart, severe pain in theregion of the stomach, nausea, vomiting and diarrhoea, salivation,perspiration, and contraction of the pupils, great weakness of thegroup of physostigmine. It is commonly referred to as fumedor pyrogenic silica because of this manufacturing process. The cerebrmn isnot affected early, as consciousness may persist almost untildeath.this alkaloid produces carisoprodol 500mg prescription free first a stimulation, then carisoprodol 500mg prescription free a depressionof the end apparatuses of the secretory, sensory and motornerve endings. cheapest generic soma 500mg online in usa a high fatty meal, acidic juices carisoprodol 500mg prescription free or antacids can delay the absorption of and delay the onset of erection. Emetine iseasily decomposed, by standing, into carisoprodol 500mg prescription free a brown body, which has lost its powers,and is therefore not used in medicine. Atropine thus acts on the central nervous system in mammalsin the same strength as hyoscyamine, but only half as strongly in the periphery.scopolamine, carisoprodol 500mg prescription free or hyoscine, resembles atropine closely in its peripheralaction, except that it passes off more quickly. For instance, purchase soma detroit the branch of obstetrics and gynecology (the female analogue of andrology) which deals with disorders of the female reproductive system has been with us for several decades now and is a well recognised specialty. (7grs.unguentum acidi salicylici (b.), sodium salicylate (c«h 4 ohcoona), awhite, odorless powder with a sweetish taste, very soluble in water, less soin carisoprodol 500mg prescription free alcohol., 10-30 grs. Helpup foundthat the subcutaneous injection of zinc salts induced congestion and parenchymatous inflammation of the kidney.zinc seems therefore to depress the central nervous system and to a lessextent the heart and voluntary muscles, and to cause irritation and congestionof the mucous membrane of the stomach and intestine and inflammation ofthe kidney. If you are carisoprodol 500mg prescription free unsure of the size, please view the size chart. At first the depth of the movement is not changed, carisoprodol 500mg prescription free butas the acceleration progresses the air inspired with each breath grad-ually becomes less. After prolonged etherization, besidesevidences of renal irritation, the mine may contain glycuronicacid, glucose, acetone and diacetic add. 1,7). (1560 it)0.) , 2.linimentum ammoniae (u.), contains about 3 per cent, ammonia. In the following carisoprodol 350mg prescription dosage years, the us pharma-ceutical industry made major contributions through carisoprodol 500mg prescription free discoveryand development of new drugs, and it assumed a place of lead-ership in the world.toward the mid-20th century, chemical research on the isola-tion, identification, and synthesis of drugs began to yield manyimportant drug substances. Erectile dysfunction that one can buy in our online pharmacy. 5% discount code for all future purchases supplied with first order! With sodium alginate, in an ultrasonic field, it has beenreported that above a minimum power output, where to buy soma panties degradation in-creased linearly with increased power.ionizing radiationionizing radiation, particularly gamma rays, has been used forthe sterilization of certain pharmaceutical products. Loiirritation of carisoprodol 500mg prescription free the gastrointestinal tract, resulting in nausea,increase in bronchial secretions, vomiting, pain in the abdomenand carisoprodol 500mg prescription free diarrhoea.when injected subcutaneously or intravenously, besides irritating the place of application, they produce in small doses sjmiptoms of gastrointestinal and renal inflammation, and in largerdoses convulsions due to stimulation of the central nervoussystem. In some cases, sperm count is so low that the only means of fertilization is artificial insemination. Combinations of iodine with oil (iodipin) or with fattyacids (sajodin) are better adapted for this purpose as they are absorbed,stored in the fat depots of the body and gradually decomposed withthe liberation of iodides. The fact that you are reading this carisoprodol 500mg prescription free article is evidence of your positive motivation to understand how your partner feels. Inchinese hamster cells it induced chromosomal damage but was questionably positive for sisterchromatid exchange. Society dictates a pursuit of the perfect penis, which focuses more on the man, rather than the couple. In amplification, rather likegtp bound to a g protein, the attachment of a phosphoryl groupto a serine, threonine, or tyrosine residue powerfully amplifies theinitial regulatory signal by recording a molecular memory that thepathway has been activated; dephosphorylation erases the carisoprodol 500mg prescription free mem-ory, taking a longer time to do so than is required carisoprodol 500mg prescription free for dissociationof an allosteric ligand. Therapeutic and supratherapeutic doses of vardenafil and the active control moxifloxacinproduced similar increases in qtcinterval. 85therapeutic application.— cocaine was formerlyused in small doses on accoxmt of its primary stimulant action onthe central nervous system. Pde5 inhibitors, including, buy cheap soma 350mg in houston and seek medical attention in the event of a sudden loss of vision in one or both eyes. Drug-protein binding does affect the abilityof drug molecules to permeate biological membranes and theirability to interact with enzymes and receptors. Blood vessel damage may lead to impotence and other health problems. Euonymus has beenemployed as a purgative more frequently than as a cardiac remedy.cumulative action. Not infrequentlythe local action of the heavy metals is supposed to be induced afterabsorption, and prescriptions are met with containing lead or iron whichare intended to stay haemorrhage from the lungs or from the kidneys.it ought to be soma prescription dosage recognized, however, that lead or soma 500mg online pharmacy mexico iron is absorbed onlyin minute quantities, and that they have no predilection for the bleedingpoints. Widespread poisoninghas been observed from the use of wines containing arsenic at hyeresin france, from milk diluted with arsenical water in london, andfrom beer in the manchester district. Priapism must be treated as soon as possible or lasting damage carisoprodol 500mg prescription free can happen to your penis including the inability to have erections. In isotonic salt solu-tion, on the other hand, muscle preserves its irritability for manyhours. Study k, the effect of 5 mg once daily on qmax was evaluated as a safety endpoint. Furosemide) is usually needed. 1 3drug and by appl)dng artifidal respiration. Anyone with a carisoprodol 500mg prescription free valid prescription carisoprodol 500mg prescription free can purchase carisoprodol 500mg prescription free finasteride online with ease.

buy carisoprodol in hanoi


At 5 years, 48% of men treated withpropecia demonstrated an increase in hair growth,42% were rated as having no change (no furthervisible progression of hair loss from baseline) and where to purchase carisoprodol online 10%were rated as having lost hair when compared tobaseline. Butmercury acts when no bile reaches the intestine and the stools are ofthe same greenish color, so that it seems likely that this arises fromthe presence of some carisoprodol 500mg prescription free mercury compound, probably some mixture ofsulphides.the mercurial purges, and in particular calomel, have often beedcredited with increasing the secretion of the bile, but this has beenshown to be incorrect, for stadelmann (in animals) and pfaflf (in man;found that carisoprodol 500mg prescription free they had no effect on the secretion escaping from a biliaryfistula. It is used for the same purposes externally.sodii phenolsulphonas, colorless cr3rstals without odor, saline taste,soluble in 5 parts water.3 to i. Results in ed patients following radical prostatectomy — was shown to be effective in treating patients who developed ed following bilateral nerve-sparing radical prostatectomy. It is slowly excreted by the kidneys; traces are foundalso in the fseces, especially if diarrhoea occurs, as is not carisoprodol 500mg prescription free infrequently the case.caesium resembles lithium in causing inflammatory carisoprodol 500mg prescription free reactions in the alimen-tary tract, leading to vomiting and diarrhoea, when it is injected hypoder-mically or when large doses are given by the mouth. This reduced exposure can be anticipated to decrease the efficacy of tadalafil;the magnitude of decreased efficacy is unknown. Given sildenafil peak plasma concentrations ofapproximately 1μm after recommended doses, it is unlikely that tablet will alter theclearance of substrates of these isoenzymes.in vivostudies:three double-blind, placebo-controlled, randomized, two-way crossover studieswere conducted to assess the interaction of tablet with doxazosin, an alpha-adrenergicblocking agent.in the first study, a single oral dose of tablet 100 mg or matching placebo was carisoprodol 500mg prescription free administeredin a 2-period crossover design to 4 generally healthy males with carisoprodol 500mg prescription free benign prostatic hyperplasia(bph). 89the results are not satisfactory enough to warrant this form oftreatment except when all others have failed.curare, dark brown resinous mass, soluble in water, varying much instrength. Theselarger doses introduce a new carisoprodol 500mg prescription free factor, however, in the direct action on the vesselwalls, which precludes the compensatory activity of the vasomotor centre, andthus the blood-pressure rises, partly from the increased efficiency of the heartand partly from the unusual resistance to the passage of the blood out of thearteries. Soma rx among other testsare observations for changes in odor, appearance, color, taste,light-stability, pourability, viscosity, isotonicity, gas evolution,microbial stability, specific gravity, surface tension, and pyro-gen content, in the case of parenteral products.when solutions are filtered, carisoprodol 500mg prescription free the filter medium may absorbsome of the ingredients from the solution. There were no adverse effects on sperm morphology or sperm motility in any of the three studies. Open house in our new york city hair restoration facility to observe a hair transplant and meet patients whose hair restoration is complete. Amphiphiliccompounds can be adsorbed onto the double lipidic membrane. Septentrionaline does not causepoisoning when taken internally, but injected subcutaneously induces localanaesthesia and later paralysis of the motor terminations like curara. Again surface-active agentsthe dispersion step 371interfacial properties order soma minneapolis 371suspensions 372settling and its control 373formulation of suspensions 374emulsions 378emulsion type and means of detection 379formation and breakdown of dispersedliquid droplets 379emulsifying agent 380preparation of emulsions 385stability of emulsions bio availability from coarse dispersions 389help greatly by lowering carisoprodol 500mg prescription free interfacial tension, which is the primary reversible component resisting droplet distortion. Toprevent excessive drop in bloodpressure, the dosage of other agents should bereduced by at least 50 percent carisoprodol 500mg prescription free when lasix isadded to carisoprodol 500mg prescription free the regimen. In isotonic salt solu-tion, on the carisoprodol 500mg prescription free other hand, muscle preserves its irritability for manyhours. Tetra-hydro-/-naphthylamine (ciohunht) raises the temperature by increasing theheat production through muscular movement and by limiting the heat lossthrough constriction of the vessels of the skin and superficial tissues. This can be done by adding various substituentsto the alkyl or acyl chain of aliphatic buy soma online india or aromatic esters or tothe ring of an aromatic ester. 37the action of ergamine on the blood-pressure (b.) and on the volume of the intes-tine and kidney in the cat. The peripheral action of atropine is thus due toits containing hyoscyamine, and as a grain of atropine contains only half agrain of hyoscyamine the former naturally exercises only half the effect of agrain of hyoscyamine. No action by internal administralion, and fleeting effecteven by intravenous injection because of ease of decomposition ofthe active principle.— extracts of suprarenalglands and solutions purchase generic carisoprodol 350mg online legally cheap of adrenalin have been employed chieflyon accoimt of their constricting influence on blood vessels, to arrest hemorrhage, and relieve the congestion of the mucous membranes of the nose, throat and eyes, as in nasal catarrh, hay fever,phar3nigitis, and conjunctivitis. Liposomes can be used to delivera wide variety soma 500mg online pharmacy mexico of drug compounds such as hydrophilic compounds in the inter-nal aqueous core and lipophilic compounds in the lipidic bilayer. The efficacy of propecia was demonstrated inmen carisoprodol 500mg prescription free (88% caucasian) with mild to moderateandrogenetic alopecia (male pattern hair loss) between 18 and 41 years of age. Paralysis of the terminations of the motor nerves in striated muscle — theso-called " curara-action" — is elicited by a large number of poisons, but infew of them is it the first effect buy cheap soma 350mg with prescription of their application. Hts allows scientists to devisebiochemical assays around a molecular target using new tech-nologies. The rest is excreted by thebowels, as under normal carisoprodol 500mg prescription free conditions but a small part of the morphine ingested is oxidized to oxidimorphine, which appears intraces in the urine. Ethnic characteristics that might influence drug effects are classified asintrinsic (related to carisoprodol 500mg prescription free the drug recipient, such where to buy soma 500mg in bangkok as patient, pathogen or tumourgenotype) or extrinsic (related buy soma 500mg in singapore to the environment or culture). The validation of a target is an importantstep in the process of targetbased drug discovery. Its action commences very soon after its admin-istration, and lasts much longer than that of amyl nitrite. Alcohol was administered in a manner tomaximise the rate of alcohol absorption (overnight fast with no food until 2 hours after alcohol).tadalafil (20mg) did not augment the mean blood pressure decrease produced by alcohol (0.7 g/kg orapproximately 180 ml of 40% alcohol [vodka] in an 80-kg male) but in some subjects, posturaldizziness and orthostatic hypotension were observed. It hasalso been stated, and denied, that the mental energy is reduced by theuse of tobacco, and an attempt has been made to demonstrate this bymeasuring the amount of work done with and without tobacco; butinvestigators are not agreed on the results, which probably dependlargely upon the individual. These dossiers are used at critical time points during the development of a new drug. The fluorides are powerful local irritants, small quantitiesapplied cheap soma 350mg in houston to the conjunctiva causing congestion and inflammation. Ciprofloxacin (cip) may buy cheap carisoprodol 350mg online in uk be prescribed to individuals allergic toamo or to those that present failure in carisoprodol 500mg prescription free the triple therapy carisoprodol 500mg prescription free 26 . (1-1£ gr.) of the pure acid, certainly a much larger quan-tity than is fatal in cases of poisoning with some of the alkaloids andglucosides. The routine treatment of pneumoniawith digitalis is often recommended, carisoprodol 500mg prescription free but is to be deprecated on thegeneral principle that buy generic soma 500mg in china a drug is not to be prescribed until some specialindication for it appears; unless distinct evidence of circulatory dis-turbance is present, digitalis ought to be withheld.in acute fevers the inhibitory mechanism is often less irritable thannormally, and the activity of the drug must not be estimated by theslowness of the pulse.in some affections of the carisoprodol 500mg prescription free heart, such as very extensive fibrous orfatty degeneration, digitalis often is of little or no service, and someauthorities deprecate its use, chiefly on the erroneous view that it mayraise the blood-pressure and increase the resistance against which theheart has to work. To znači da ih isto toliko ne prikuplja u dovoljnoj mjeri podatke koji im mogu pomoći da bolje postave ciljeve i izaberu strategiju. Qt prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (e., carisoprodol 500mg prescription free severe dizziness, fainting) that require immediate medical attention. Greenland welcomes a new employee, parnuna egede, as an advisor on environmental issues with a half year carisoprodol 500mg prescription free position until at least july.

where to purchase carisoprodol 350mg online europe

Thecells of the stomach first attacked are those of the glands, and thecondition has been termed gastradenitis.the liver is early involved in the action of phosphorus, and fischlerand burdach state that the fatal dose is much higher than usual inanimals in which the poison is delayed in reaching carisoprodol 500mg prescription free that organ; theydemonstrated this in dogs in which free communication had beenestablished between the portal vein and the inferior cava, so thatthe liver circulation was reduced to the hepatic artery.the fatty changes in the liver cause a considerable increase in thearea of hepatic dulness, and at the same time induce some pain andtenderness over the organ.in the earlier phases the secretion of bile pigment is increased,denoting an unwonted activity of the liver, but later as the cellsbecome infiltrated with where to buy carisoprodol in the uk online fat, they press on the bile capillaries andocclude them, so that the bile is absorbed into the bloodvessels andgives rise to jaundice. The preparations of bitter almonds, except theexpressed oil, contain it, and the volatile oil is, in fact, dangerous owing to thelarge proportion of prussic acid sometimes present. Padgett medical center, it only takes one visit and you can be free of the symptoms that cause erectile dysfunction. Therefore favorable results were rarely obtained.nowadays, these drugs are used almost exclusively for hemorrhage in the uterus. It is employed in glaucoma to decreaseintraocular tension. The kinetics of ciprofloxacin in patients with acute hepatic insufficiency, however, have not been fully elucidated [see use in specific carisoprodol 500mg prescription free populations]. Stimulation ofthe hypogastric nerve or adrenaline now causes inhibition and relaxation.u. Thus, studies of the carisoprodol 500mg prescription free relation between struc-ture and activity of a carisoprodol 500mg prescription free series of agonists and antagonists can identifya species of receptor that mediates a set of pharmacologicresponses.exactly the same experimental procedure can show thatobserved effects of a drug are mediated by different receptors. Surgery cheap soma 500mg with paypal to correct an injury or blood vessel problem may be needed if other impotence treatments have failed. News, sermitsiaq and other media were on the carisoprodol 500mg prescription free spot when icc had the purchase carisoprodol columbus inuit and arctic indigenous peoples day at the cop15 arctic venue in copenhagen. More recently cholesterin has been suggestedas the curative agent, but it is present in smaller quantities in codliver oil thanin carisoprodol 500mg prescription free many other foods. These attitudes and values have health care implications. Pneumoniaesusceptibility should be tested using amoxicillin powder. Sometimes the urine is entirely suppressed from thetubules being plugged with blood cells and debris, and intense icterus appearsfrom the formation of excess of bile-pigment from the haemoglobin of thedisintegrated corpuscles. Stabilizing factors include the presence of electrical charges at theparticle surface and the presence want to buy carisoprodol 500mg online legally of adsorbed macromoleculesor nonionic surfactants. Another factor that must be kept in mind is thatcharged solid surfaces, such as polyelectrolytes, will stronglyadsorb oppositely charged solutes. This consists of colorlesscrystals with an acid saline taste, readily soluble in water. Amoxil, in combination with clarithromycin ambien 10mg order online uk plus lansoprazole as triple therapy, is indicatedfor the treatment of patients withh. For example, regular (every 6 weeks) on-site visits buy soma 350mg with visa to theinvestigator centres are done by what are called clinical study monitors (csm)or clinical research associates (cra) who verify all source data (100% sourcedata verification or sdv). Attenzione: they actin lower dilution on the central buy cheap carisoprodol 500mg tablets nerve cells, however, and do not affect thesensory fibres more than the motor, while the concentration of cocaine whichaffects the nerve cell is less distant from that which acts on the peripheralfibre and it acts much more strongly on carisoprodol 500mg prescription free the carisoprodol 500mg prescription free sensory than the motor nerves.most of the other natural alkaloids resemble cocaine in many points oftheir carisoprodol 500mg prescription free action, as far as they have been investigated, but where to purchase carisoprodol in australia some of the artificialcompounds present divergences from the general type. Thissolvent action occurs more readily when the blood cells are suspendedin normal salt solution than in the plasma or serum, because the carisoprodol 500mg prescription free choles-terin of the serum forms inactive compounds with the saponins. Quinine has no hemolytic action except in quantitieswhich would prove immediately fatal, and the blood of these black-water patients is not more readily laked by carisoprodol 500mg prescription free it than normal blood.the uterus is aroused to contraction by quinine, and abortion occursoccasionally after its use in malaria, while in other cases labor painsmay be induced. Forexample, treatment of febrile episodes in neutropenic cancerpatients with empiric antimicrobial therapy has been demon-strated to have impressive morbidity and mortality benefits eventhough the specific bacterial agent responsible for fever is deter-mined for only a minority of such episodes.finally, there are many clinical entities, such as certain epi-sodes of community-acquired pneumonia, in which it is diffi-cult to carisoprodol 500mg prescription free identify a specific pathogen. Thus in bronchitis, more especiallyin cases of old standing, the addition of squills to an "expectorantmixture" is often followed by the most satisfactory results. But the popular pfizer company comes up with an incredible medicine commonly called as blue pill. Quinine acts probably throughreducing the metabolism, and alcohol by dilating the skin capillaries,and perhaps by lessening the movements and thereby the formationof heat. A clinical holdcan be issued by the us fda to delay or to suspend a previously approvedclinical trial. In a pharmacokinetic interaction study, azithromycin did not alter the anticoagulant effect of a single 15 mg dose of warfarin administered to healthy volunteers. The bileis generally more dilute than normal, the fluid increasing more thanthe solids, though the total solid excreted is augmented.salicylate has been said to lower the normal temperature, but thisseems to be erroneous, except when very large quantities producea condition akin to collapse. Morphine is used in cases of diarrhwas to decrease theperistalsis and the secretions of the intestines. The time point at which the decision is made to start a phase 3 clinical trial is generally referred to as theendof phase 2. He/she should purchase valium 5mg online ireland givedirect access to these documents as well as to trialrelated source where to buy soma online with american express data tosponsor personnel (monitors, auditors) and inspectors. Ethnic characteristics that might influence drug effects are classified asintrinsic (related to the drug carisoprodol 500mg prescription free recipient, such as patient, pathogen or tumourgenotype) or carisoprodol 500mg prescription free extrinsic (related to the environment or culture). The truth is that alcoholic beveragesusually increase appetite on accoxmt of their pleasant taste andlocal irritant effect on the mouth and stomach. Atropine and its congenersare contraindicated where there is any suspicion of glaucoma, as,owing to their action carisoprodol 500mg prescription free on the intraocular pressure, they may eitheraggravate the disease already present or precipitate an acute attack.332 substances acting after absorptionwhen dilatation of the pupil is necessary and there is reason to ap-prehend the results on the intraocular pressure, homatropine should beemployed, as its effects can be readily controlled by eserine. Has been providing for many years to private businesses. In addition, this list con-tains therapeutic equivalence evaluations for carisoprodol 500mg prescription free approved multi-source prescription drug products. Impaired sexual response after lesions of the paraventricular nucleus of the hypothalamus in male rats. Perhaps this action in relax-ing spasmodic contractions may carisoprodol 500mg prescription free also explain the beneficial effectsobtained in cases of incontinence of urine in children, in which bella-donna has long been the carisoprodol 500mg prescription example most reliable remedy.to lessen pain. Alprostadil may also be administered carisoprodol 500mg prescription free into the urethral opening of the penis. Mostdrugs unite where to buy carisoprodol 350mg online no prescription chemically with some constituents of carisoprodol 500mg prescription free the organism,and, by virtue of this union, change its functions. Afterthe stimulation there succeeds depression, which follows the stimu-lation carisoprodol 500mg prescription free downward, affecting first the cerebrum and then the lowerdivisions. The blood undergoes characteristicchanges when it is acted on by saponin either in the vessels or in thetest-tube. The efficiency of present-day emulsifiers permits the preparation of emulsions thatare stable for many months carisoprodol 500mg prescription free and even years, even though theyare thermodynamically unstable.in recent years, it has been recognized that complex multiple-phase combinations can exist in emulsions. But these owe their use, not to the calciumion, but to the other part of the molecule — the anion. Binz found that whilevery minute quantities sometimes increase the movements of theamoeba and infusoria at first, large amounts paralyze them imme-diately, and the protoplasm assumes a darker granular carisoprodol 500mg prescription free appearance.the rhythmic movements of ciliated organisms are rendered slow andfinally arrested by very dilute solutions, but no other organism is sosusceptible to the action of quinine as those which induce malaria inman.

Laisser une réponse

Votre adresse de messagerie ne sera pas publiée. Les champs obligatoires sont indiqués avec *