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Either the clinical developmentplan explores these differences from the purchase generic klonopin 1mg online no prescription start with specific studies in early drugdevelopment, followed by multi-regional clinical trials in late development, oralternatively, the clinical development is conducted entirely in one region orpopulation, and is later supplemented with a bridging study in (each of) thenew region(s) or population(s) in order to purchase generic klonopin 1mg online no prescription verify whether the initial resultscan be used to substantiate worldwide drug approval.there are numerous operational and logistic challenges to conduct a globaldrug development programme, especially with regard to large multi-regionalclinical trials, such as:- sufficient knowledge of region- or country-specific regulatory require-ments;- identification and choice of participating countries and investigator sites;- production of study drugs and management of the drug-supply chain(including customs clearance); - document handling in different languages; and- monitoring or auditing of sites all over the world.therefore, most (even large multinational) pharmaceutical companies tend tooutsource all or part of these activities to large full-service contract researchorganisations (cros) that operate worldwide, but without delegating eithertheir responsibility or their accountability.finally, the globalisation of drug development has had a profound impacton the geographical distribution of locations where clinical trials are per-formed. If you are also using a nitrate drug for chest pain or heart problems (such purchase generic klonopin 1mg online no prescription as nitroglycerin). Together the molecules form a highlycondensed film, despite the presence of a high number of likecharges. It isexcreted into the stomach and intestine, in the urine, and, it is said, in the bileand milk. More benefit is derived from the treatment of gout and rheu-matism by the alkaline mineral cheapest generic klonopin online in canada waters than by artificial preparations,and this is especially marked when patients are purchase generic klonopin 1mg online no prescription sent to the mineralsprings. When thehead is about to emerge, on the other hand, a large dose may be givento promote the permanent contraction of the uterus and thus to preventpost-partum haemorrhage. None of it is found in the epithelium of the stomachand intestine, and some of it may circulate in the blood in a soluble formfor a short time. Online, now you know where you can do this fast and easy. It is very closely allied to atropine,and is decomposed into tropic acid and scopoline (oscine), which isnearly related to tropine.a number of other alkaloids have been described in different plants, generallyassociated with one or more of those already mentioned. Risk assessment before starting fih studies; risk-based clinicaltrial management; risk-adapted clinical trial monitoring; risk-based auditsand inspections; and risk management plans in relation to drug safety; butthere is still a long way to go. However, appropriate clinical advice should be given to patients regarding a possibledecrease in blood pressure when they are treated with antihypertensive medicinal products.preclinical studies showed an additive systemic blood pressure lowering effect when pde5 inhibitorswere combined with riociguat. The latter channel has been found to bepreferable because the absorption and excretion can be more easilyregulated purchase generic klonopin 1mg online no prescription and the irritation is less than by most of the others.except for a very small amount which passes out by the kidneys, ether is almost entirely excreted by the lungs. Klonopin order online canada the excretion in the urine begins within an hour whenmercury is injected where to buy klonopin 1mg online with paypal intravenously, but more slowly by the ordinarymethods of administration; for example, after inunction, none may befound for purchase generic klonopin 1mg online no prescription twenty-four hours. You where to purchase clonazepam 2mg tablets may need to take propecia daily for three months or more before results are visible. An oldmethod of inducing this effect is by burning paper impregnated withsaltpeter and inhaling the fumes, which contain nitrite formed by buy drug klonopin 2mg with prescription thereduction of the nitrate.slight increase in the urine is observed, at other times a decrease, andafter large quantities anuria may occur. Effect of testosterone administration on purchase klonopin 2mg in australia sexual behavior and mood in men with erectile dysfunction. Presumably this occurs, as seen in figure 19-14, by arranging the molecules so that ionic groups alternate with alcohol groups; however, if chain–chain interactions are not strong,the ionic species purchase generic klonopin 1mg online no prescription often will be displaced by the more nonpolarun-ionized species and will “desorb” into the bulk solution.on the other hand, sometimes the more soluble surface-active purchase generic klonopin 1mg online no prescription agent produces surface purchase generic klonopin 1mg online no prescription pressures in excess of the collapsepressure of the insoluble film and displaces it from the surface.this is an important concept because it is the underlying principle behind cell lysis where to buy clonazepam 2mg online legit by surface-active agents and some drugs,and behind the important process of detergency. Homogenization speed and time and rate of cooling may influence theviscosity of the product. There are no welldefined dedicated laws for online pharmacies. In the case purchase generic klonopin 1mg online no prescription purchase generic klonopin 1mg online no prescription of metered-dose inhaler pulmonaryaerosols, purchase meridia in uk particle aggregation may result in inadequate lung de-position of the medication.the chemical causes of drug deterioration have been clas-sified as incompatibility, oxidation, reduction, hydrolysis,racemization, and other mechanisms. No other drugapproaches it in this purchase generic klonopin 1mg online no prescription galactagogue effect. They are aspidospqrmine,aspidospermatine, aspidosamine f hypoquebrachine, quebrachine, and quebra-chamine. Thirty-two (32) males (62%) ofthe patients completed the trial. Generic drugs are copies of theoriginal drugs developed by the rd drug industry and can be introduced inthe market after it is shown that they are bioequivalent with the original drug. Thussyphilis and several of the exanthemata are generally acceptednot to recur during the lifetime of an individual. — where a special idiosyncrasy exists, quininemay be unsuitable, but these cases are far rarer than is generallybelieved. The terminations of the nerves in theheart are not affected, but the nerves of the lymph hearts of the frogare paralyzed. As mentioned above, the depressant actionof alcohol on the heart is much purchase generic klonopin 1mg online no prescription less than that of chloroform, sothat, purchase generic klonopin 1mg online no prescription unless there are some previously existing purchase generic klonopin 1mg online no prescription pathological conditions in the heart, death usually purchase generic klonopin 1mg online no prescription restdts from buy drug klonopin online with american express paralysis of therespiratory centre before the heart is stopped.death from acute alcoholism is infrequent, and the chronicabuse is a much more alarming factor in civilization. These symptomsare partly subjective and indefinite, such as headache, wanderingpains, or general weakness, while others are evidently due to circulatorychanges, and consist of a feeling of fullness and congestion of the head,palpitation of the heart, and acceleration, sometimes weakness, of thepulse. But the clot-dissolving drug must be administered within three hours of initial stroke purchase generic klonopin 1mg online no prescription symptoms for effectiveness. The intravenous administration wastherefore adopted and has become the ordinary method, althoughsome purchase generic klonopin 1mg online no prescription authorities hold that the intramuscular administration wasabandoned prematurely.when salvarsan is injected intravenously, there purchase generic klonopin 1mg online no prescription are as a generalrule no symptoms elicited, but in individual cases effects varying fromcomparatively trivial disturbance to clonazepam prescription writing grave and even fatal issues havebeen met purchase generic klonopin 1mg online no prescription with.the symptoms more commonly described are headache, giddiness,nausea and malaise, and fever; sometimes vomiting and diarrhoea occur,606 substances acting after absorptionand jaundice, dyspnoea, restlessness and tremors, profuse sweating,and exanthemata of various kinds have occasionally been seen. Some are taken in pill form, or are put on the skin of the penis. It has beenused successfully by this author and others in the treatment ofconstipation. Even small quan-tities of strong sulphuric acid striking the eye are sufficient to destroythe sight.in the mouth, (esophagus, and stomach, the corrosive action is evi-denced by complete destruction of the mucous membranes which comein contact with the strong acid. Wherever cancellous bone is being formedfrom cartilage, phosphorus is stated by wegner to cause the depositof a layer which resembles the dense bone of the shaft in the normalanimal in general appearance and also histologically. Numerous examplesare described in other sections of this book, and the literatureis replete with illustrations.although undesirable reactions between two or more drugsare said to result in aphysical, chemical,ortherapeuticin-compatibility, physical incompatibility cheapest generic klonopin online europe is somewhat of a misno-mer. purchase generic klonopin 1mg online no prescription even when apreparation is accurately standardized in the content of alkaloids,as in the u. Om dit weer te geven, moet je javascript purchase generic klonopin 1mg online no prescription inschakelen en adobe flash 9 of hoger installeren. You can search our store for something for everyone on where to purchase klonopin online legitimate your gift list or shop for yourself (our personal favorite). A few useful drugs have been known since humans first beganingesting or injecting substances and recording the results.er 1), but the majority of agentsin current use have been developed during the last 100 years usinga variety of pharmacologic and toxicologic techniques. Conditions and terms of use applicable to all users of this site. This center also oversees ra-diation-emitting devices, such as lasers, x-ray systems, micro-wave ovens, and cellular telephones. Even in organs in which the vessels aremore obviously constricted, the degree varies considerably, apparentlyaccording to the amount of control normally exercised by the constrictornerves; thus the vessels of the uterus are more contracted than those ofthe bladder, and these again purchase generic klonopin 1mg online no prescription more than those of the striated muscles.after moderate quantities of adrenaline the blood-pressure fallsagain after about five minutes, and not infrequently descends belowthe normal level. Gelatincapsules should be protected from sources of microbial con-tamination. Stimulation of the central nervous system is followed by depression. Do not store in the bathroom.

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As a rulethe active principles do not act so well as the crude drugs, purchase generic klonopin 1mg online no prescription probably because the colloidal substances in the latter prevent rapidabsorption and decomposition, thus keeping them longer in contact with the mucous membrane.simple purgative series.oleum ricini (u.), castor oil, a yellowish, viscid fixed oilexpressed from the seeds of ridnus communis. In recent years it has been disputed whether purchase generic klonopin 1mg online no prescription iron, purchase generic klonopin 1mg online no prescription \manganese, copper and other metals are absorbed at all, but investiga-tion with more accurate methods has shown that iron and manganesepass into the tissues from the alimentary tract, and it seems probablethat a small proportion of most of the metals finds its way into theblood. That progression of purchase generic klonopin 1mg online no prescription mitral regurgitation (mr) is associated with development of endothelial dysfunction. In top most quality securing your budget from being wasted on comparatively low base medications which would, ultimately, compromise you impotence treatment. Contrast the effects of inhibition alonein figs. From hair loss to body weight, the media projects an ever-youthful image for men purchase generic klonopin 1mg online no prescription to embrace. Cantharidin is excreted by the kidneys.the susceptibility of cantharidin towards different animalsvaries enormously; thus in the hen and hedgehogs large quantities may be taken without much effect, while in the rabbit a smalldose, as in man, will produce intense sjmiptoms of poisoning.capsaicin, mezerein and euphorbin have much the sameaction as cantharidin.when extracts of poison ivy or solutions of its active alkaloidare applied to the skin, or when persons are accidentally poisonedby the plants, a feeling of warmth and itching buy generic klonopin 1mg no prescription develops in fromtwentyfour hours to eight days after exposure. This decrease was associated withan increase in fecal excretion of metabolites.plasma concentrations of metabolites were significantly higher in patients with renal impairment (basedon a purchase generic klonopin 1mg online no prescription 60% increase in total radioactivity auc). In white hellebore, protoveratrine is accompanied by jervine,pseudo jervine, rvbijervine, protoveratridine f and others. (see precautions: severe dizziness, fainting, fast/irregular heartbeat.this medication may rarely cause a severe intestinal condition purchase generic klonopin 1mg online no prescription (pseudomembranous colitis) due to a resistant bacteria. The mode oftransmission of disease and the pathogenicity, virulence, purchase generic clonazepam 2mg in uk and buy drug clonazepam 1mg online with paypal in-vasiveness of the infectious microorganisms are under investiga-tion. The increase in the blood pressure is due to the augmented purchase generic carisoprodol 500mg in china force of the purchase generic klonopin 1mg online no prescription heart plus contraction of the peripheralvessels. The movements of plant protoplasm, protozoaand leucocytes are prevented by salicylic acid as by quinine and theother aromatic antiseptics. Do not take the drug if you suffer from hepatic or renal impairments. In this search, microorganisms from planttissues, animal sources, clonazepam 2mg prescription mg the sea, many types of soil, and manyother ecological want to buy clonazepam 1mg online legally from canada niches have been examined. Anaphylaxis isonly developed after 10-14 days, so that repeated injections may bemade without danger for a week or more.apart from their action on the toxins, serums may also be specifi-cally purchase generic klonopin 1mg online no prescription bactericidal, destroying or retarding the growth of the bacilluswhile affecting the toxin to a less extent. Peyronie's disease, which causes purchase generic klonopin 1mg online no prescription the penis to bend to one side during erection. These may be buy klonopin in florida followed by someconfusion and dulness and by indistinct sight and hearing. Benzoic acidoften increases the nitrogen eliminated in the urine, so that in thesecases it augments the decomposition of the proteins like salicylic acid;in other investigations no material change has been observed, probablybecause the benzoic acid was changed too rapidly to hippuric acid toadmit of its action on the metabolism being developed. Digitalis, however, order klonopin in korea as is now conceded by almost every-one, causes some increase in the quantity of urine secreted by thenormal animal, although this is small compared with that in cases ofdropsy. Decomposed by alkaline fluids of theintestines into phenol and salicylic acid.it has no action on the stomach because it remains insoluble in add juicesand purchase generic klonopin 1mg online no prescription so it can be used to coat pills destined for intestinal action. Use of erectile prostheses in patients with free forearm flap phalloplasty. Patients purchase generic klonopin 1mg online no prescription should beadvised to contact their healthcare provider for dose modification ifthey are not satisfied withthe quality of their sexual performance with levitra or in the case of an unwanted effect.patients should be advised to contact the prescribing physician if new medications that mayinteract with are prescribed by another healthcare provider.physicians should advise patients to stop use of all pde5inhibitors, includingand seek medical attention in the event of sudden loss of vision in one or both eyes. Bothof these purchase generic klonopin 1mg online no prescription subjects were protocol violators,one due to a low baseline standing sbp, and the other due to baseline orthostatic hypotension.in the second study, a single oral dose of tablet 50 mg or matching placebo was administeredin a 2-period crossover design to 20 generally healthy males with bph. 429; xxviii, p. In con-sidering their effects on the central nervous system it must be remem-bered that those containing much atropine are more stimulant, thosewith hyoscine more sedative. In the iris of the mammals, vhich consists of un-striated muscle, curara has no effect, while the striated muscle of thebird's iris ceases to respond to stimulation of the motor oculi, butcontracts on direct stimulation. The development purchase clonazepam 2mg mastercard of bone from cartilage is notthe only process affected, however, for wegner states that in the bonedeposited from the periosteum a somewhat want to buy clonazepam 2mg online legally from canada similar change is induced,as is shown by its becoming denser and by the haversian canals beingmuch contracted in size. It is possible, also, that at any rate some of purchase generic klonopin 1mg online no prescription themembers of this series act as slight irritants to the renal epithelium.the appearance of blood and albumin in the urine of animals afterlarge doses of squills and digitalis certainly indicates some local actionapart from the circulatory changes.the changes in the circulation in man can purchase generic klonopin 1mg online no prescription be followed only imper-fectly because there is as yet no means of measuring the strength purchase generic klonopin 1mg online no prescription andefficiency of the heart contractions. These purchase generic klonopin 1mg online no prescription audits can take several days, can eitherbe conducted before, during or after the end of a study or the submission ofa clinical trial or marketing authorisation application, and can be performedroutinely or tor cause (whenever a potential problem has purchase generic klonopin 1mg online no prescription been identified thatwarrants further checking). Tyramine or hydroxyphenylethylamine, and ergamine or histamine (0-iminazolylethylamine,jy-j r yc.ch2.nh2) along with several less important basessuch as isoamylamine and acetylcholine are also present in ergot. Treat this symptom with Zovirax Cold Sore Cream and you could stop the coldsore appearing. These drugs increase the efficacy of no, which dilates the blood vessels of corpora cavernosa. The same criticism might be appliedto the ergot treatment of a number of other diseases, such as aneurism,diabetes, or pneumonia; and in addition, it does not seem to have anygreater effect in these than many other less dangerous remedies, whichhave been equally vaunted as specifics, and have been found equallyvalueless.t attended with any obvious result, while the intravenousinjection of purchase generic klonopin 1mg online no prescription the aqueous extract causes pronounced effects in a numberof organs, especially on those containing involuntary muscle. For example, general anesthesia can be achieved with theinfusion of ketamine, 1545 mcg/kg/min, plus 50-70% nitrousoxide or by ketamine alone, 30-90 mcg/kg/min.small bolus doses of ketamine (0. The process addsan extra diagnostic step before providers can determine whichdrug will provide the most appropriate treatment option.one latest example of personalized medicine is a purchase generic klonopin 1mg online no prescription genetic testthat will help the practitioner predict which patient with acutecoronary syndrome (acs) requires a higher dose of clopido-grel. This is due to the fact that the bloodsupply is simultaneously reduced by the vasoconstriction, for edmundshas shown that the secretion of the pancreas is arrested by adrenalinecausing ischa?mia of the gland. These are carisoprodol online usa pharmacy easily absorbed and easilyexcreted so that the intensity of action can be convenientlyregulated.

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Midazolam (1-2 mg iv) is effective forpremedication, sedation during regional anesthesia, and brieftherapeutic procedures. Such failure of the pump function maybe chronic, in which case symptoms of fatigue, ankle swelling,effort dyspnoea and orthopnoea predominate, or it may beacute, with sudden onset of shortness of breath due to pulmonary oedema (figure 31. The stimulant action on the peripheral organs and especially on those of sweat and salivation,forms the striking feature of the action of pilocarpine. Thepowdered leaves may be given in the form of pills. This increasedexcitability in the pacemaker leads to acceleration of the beat of thewhole heart, but larger amounts arouse the normally dormant areasin the auricle and ventricle, and lead to impulses being dischargedfrom them and causing contractions in one part of purchase generic klonopin 1mg online no prescription the heart which arenot shared in by the rest of purchase generic klonopin 1mg online no prescription the organ. In a certain proportion of malignant formsmercury is unable to arrest the progress of the disease. Since the molecular environment of the protons can producecharacteristic shifts in the proton nmr spectrum, nmr is a powerful tool inthe identification of molecules in medicinal chemistry and chemical purchase generic klonopin 1mg online no prescription develop-ment. 131the decrease of febrile temperature is sought, either when thelatter becomes purchase generic klonopin 1mg online no prescription dangerously high or when there is marked discomfort from it. Following buy klonopin new york sexual stimulation works by helping the bloodvessels in your penis to relax, allowing the flow of blood into your penis. A great purchase generic klonopin 1mg online no prescription deal of weight was formerly laidon the use of purgatives and emetics as preliminaries to the treat-ment of malaria with quinine, and purchase generic klonopin 1mg online no prescription the former are undoubtedly ofservice sometimes, although it is unnecessary to delay the quininetreatment by waiting for the intestines to be evacuated.quinine is used not only purchase generic klonopin 1mg online no prescription as a remedy, but also as a purchase generic klonopin 1mg online no prescription prophylacticagainst malaria. It was believed that theaffinity of mercury for nitrogen being satisfied in these compounds, it wouldattack the proteins less, and cheapest generic clonazepam online europe as a matter of fact, the injections are said to beless painful that those of corrosive sublimate. Similarly, the dose required to produce a particulartoxic effect in 50% of animals is called the median toxic dose(td 50 ). Purchase generic klonopin 1mg online no prescription moreover, emerging buy klonopin 1mg with prescription results from an ongoing study may prompt a change in the developmentstrategy or identify the need for additional studies from a previous category.for example, some specific human pharmacology trials, such as a qt intervalstudy, are generally performed during late clinical development.the scientific and functional disciplines that contribute to the clinical development stream are: this stimulation by small quantities seems limitedto the inhibitory cardiac centre in the medulla oblongata, but whenlarger doses of digitalis purchase generic klonopin 1mg online no prescription and its allies clonazepam 1mg visa are injected, other parts of themedulla become stimulated, and vomiting, increased respiration, andeventually general convulsions may be produced.the extent to which purchase generic klonopin 1mg online no prescription the members of this series act as stimulants tothe nervous centres varies, but as yet little comparative work has beendone in this direction.the action of the heart is the most important of all, and is whatdistinguishes digitalis and its buy drug klonopin 1mg online with mastercard allies from all other substances. The ferments whichdecompose the amino-acids do not seem more active in phosphoruspoisoning or in autolysis than normally, but only those which decomposethe proteins to their simpler bodies. The results obtained since its introduction byroux have been astounding. As a result, water soluble preservatives are more effective, because the concentration of theunbound preservative in the aqueous phase assumes a greatdeal of importance in inhibiting the microbial growth. Actually started out in studies as a medication to reduce blood pressure. Time it's a suitably open-ended name for a record that purchase generic klonopin 1mg online no prescription presents a side of mathew jonson you've never heard before. Purchase generic klonopin 1mg online no prescription it is also liquefied when rubbed withchloral, camphor, menthol and phenol. Smalldoses slow the pulse and increase the blood-pressure, while larger arefollowed by greater slowing of the heart and a fall in the blood-pressure.the slowness of the pulse is due to the poison acting on the heart directlyand not to any inhibitory interference, for it occurs after large quantitiesof atropine. The subjects should havebeen drug-free for at least two weeks prior to testing to elimi-nate possible drug-induced influences on liver enzyme systems.normally, the subjects will fast overnight for at least ten hoursprior to dosing and will not eat until a standard meal is providedfour hours post-dosing. It is usually dispensed in glass pearls which can be brokenin a handkerchief and inhaled during attacks. Either the pure alkaloid or the crude drug which hasbeen standardized on frogs, may be administered in the presence of a medical attendant who should always be ready to perform artificial respiration. Later it is liable to injure the patient by purchase generic klonopin 1mg online no prescription its action on thedigestion, and in some cases has induced abortion; the child purchase generic klonopin 1mg online no prescription may alsosuffer clonazepam 1 mg from mercurial poisoning. Somesymptoms have been observed when it is rubbed on the skin in a stateof fine division, and these are probably due to its absorption in theform of an oxide. As regards klonopin 2mg prescription requirements the irregularities in these non-fibrillating cases, there isno reason to believe that digitalis has any direct action on them, thoughthe purchase generic klonopin 1mg online no prescription lowest tracing is given by the radial artery, the next by the jugular vein, whilethe time is given in one-fifth seconds above. The muscles and peripheral nerves are notaffected by morphine except when buy klonopin oklahoma city applied in overwhelmingamoimts, and this drug is in no sense a local anaesthetic.group of morphine. Strictly adhering to a gluten-free diet has enabled some men, who previously thought they were sterile, to become fathers. Nidoux made quantitative determinations of ether inthe blood under various stages of narcosis. 216.472 substances acting after absorptionforms, such as red, erythematous, itching patches or more widelydiffused hyperemia resembling the onset of measles purchase generic klonopin 1mg online no prescription or scarlatina;urticaria occurs not uncommonly, while eczema and bullae are rarer.in some cases an oedematous swelling has been purchase clonazepam online legitimate observed. There exists no query that buy cheap alprazolam in hanoi chronic alcohol abuse, a leading worldwide problem, causes neuronal dysfunction and brain damage. Much still remains tobe investigated, but it has at least been determined that it is muchmore efficacious in certain forms of cardiac impairment than in others.its most remarkable therapeutic effects are seen in cases of auricularfibrillation, for purchase generic klonopin 1mg online no prescription which it may be said to be a specific comparable onlyto quinine in malaria. This chronic poisoning, or mercurialism, isdue, not to the local action, but to the effects of the drug after ab-sorption. Great caution should be exercised meridia sales in the use of chloralor, in fact, purchase generic klonopin 1mg online no prescription any other narcotic of this group when there is presentorganic weakness of the heart.it was formerly asserted that stdphonal, veronal, but especiallyparaldehyde and urethane were perfectly safe drugs, but all haveagainst them a record of deaths following purchase generic klonopin 1mg online no prescription their administration.sulphonaly tetronal, trional, veronal, neuronal, isopral,etc., have all been prescribed chiefly in powder or tablet form onaccount of their rather difficult solubility in water: it may produce marked muscular spasm, tremors andconvulsions. At presentipecacuanha is used chiefly as an expectorant in the treatment ofinflammatory conditions of the respiratory passages. Rodents, dogs) and records of source,date of arrival and arrival conditions should be maintained. In the herbivora the reaction changes fromalkaline to strongly acid, and large quantities of the salts of the alka-lies appear, while in the carnivora some increase in the sodium andpotassium of the urine occurs along with a much greater increase inthe ammonia. For example, anxiety or depression may be caused purchase generic klonopin 1mg online no prescription or worsened by problems with your sex life. This rather simplededuction can be sophisticated by bringing in the timerelated value of moneyas income today is worth more than income next year and early expenditure ismore costly than later expenditure. Nitrolingual, nitro-dur, nitro-bid, and others), isosorbide dinitrate (dilatrate-sr, isordil, sorbitrate), and isosorbide mononitrate (imdur, ismo, monoket). In these cases chain entanglements provide thesole temporary crosslinks.

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